CV Science

Philippe Pasero PhD Cell Biology

Course and current status

Current position: Principal Investigator (DR1 Inserm)
Institute of Human Genetics (IGH) CNRS UPR 1142
141, rue de la Cardonille - F-34396 Montpellier Cedex 5

2011-2014    Deputy Director of IGH, Montpellier, France

2006-2011    Senior group leader (DR2 Inserm) at IGH, Montpellier

2003-2006    Junior group leader (ATIP, EMBO YIP) at IGH, Montpellier

2000-2003    Staff scientist (CR1 INSERM) at IGMM, Montpellier

1998-2000    Postdoctoral fellow in the lab of E. Schwob at IGMM, Montpellier

1994-1998    Postdoctoral fellow in the lab of S. Gasser at ISREC, Lausanne, CH

1990-1993   PhD student, University of Aix-Marseille

Scientific summary

A central question in cancer biology is how genomic instability arises in normal cells. Recent evidence indicates that replication stress is detected very early during the cancer process and contributes to the development of the disease. Our research focuses on the origin of this replication stress in yeast and in human cells. We use powerful new technologies such as DNA combing and ChIP-seq to monitor replication fork arrest and recovery at the level of individual molecules and on a genome-wide basis. These studies should provide new insights into how DNA replication errors promote the development of cancer and of other genetic disorders associated with increased genomic instability.