Scientific topics
Keywords
Pascal Peraldi PhD
Course and current status
1995: PhD at the university of Nice Sophia Antipolis (France) on tyrosine kinases and phosphatases director: E. Van Obberghen
1995-1997: Post Doc in B. Spiegelman laboratory (Harvard Medical School, Boston, USA) on TNF-a and insulin resistance
1997-2002 : CR INSERM (tenured scientist) at INSERM U145 Nice (France) demonstration of the function of SOCS protein in insulin resistance
2002-now: CR INSERM (tenured scientist) at CNRS UMR 6543 Nice (France) study of stem cells and Hedgehog signaling
Scientific summary
My scientific interest have always been the study of molecular mechanisms involved in normal and pathological aspect of adipocyte and their differentiation.
Recently I studied how Hedghog (Hh) signaling controls the fate and differentiation of human mesenchymal stem cells (hMSC).
We have shown that Hh inhibits osteoblast differentiation of hMSC and the maturation of adipocytes. By contrast , inhibition of Hh signaling inhibits proliferation and clonogenicity of hMSC.
These data shed a new light on the function of Hh signaling and could be of consequences in the developement of pathologies associated with an abnormal development of adipose tissue such as obesity and its associated pathologies.
