Arnaud B. Nicot PhD Molecular Biology, Neurobiology.

Course and current status

o     2010-   : Associate Prof. (Chargé de Recherche CN), Inserm-Nantes University UMR 1064, CHU Nantes. Neuroinflammation, estrogen, steroid metabolism, multiple sclerosis, autoimmunity, lymphocytes, antibodies.

o     2004-09: Associate Prof. (Chargé de Recherche 1), Inserm-UPMC UMR 732 & 546, Paris. Chemokines, estrogen and autoimmune neuroinflammation.

o     2002-03: Research Associate, Dept Neuroscience, University of Medecine and Dentistry of New Jersey, USA. Neuronal pathology in murine models of multiple sclerosis and spinal cord injury.

o     1997-2001: Research Associate, Dept Neuroscience and Cell Biology, University of Medecine and Dentistry of New Jersey, USA. PACAP control of neural precursor proliferation.

o      1995-96: Postdoctoral Fellow, Lab. Neurobiology and Behavior, Rockefeller University, NY, USA. In vivo antisense strategy, estrogens and behavior.

o     1993-95: Visitor, Medical Pharmacology/Center for Biopharmaceutical Sciences, Leiden, The Netherlands. Neurotensin antagonists & stress. Inserm-NWO exchange & Biomed 1 european program.

Scientific summary

My reseach covers autoimmunity and neuroinflammation, with translational research for defining new therapeutical strategies. We addressed the issues of lymphocyte involvement in CNS damage and reactive astrogliosis in murine models of multiple sclerosis, an autoimmune disorder of the central nervous sytem, in which the myelin sheet and oligodendrocytes have been regarded as major primary targets by the immune system. Reevaluation of the pathological processes in animal models and flow cytometry, scRNAseq or imaging studies in humans now indicate the involvement of several cellular players including astroglia in early pathology and progression to chronicity.  Current work further focuses on defining immunological targets in the context of multiple sclerosis as wel as reactive astrogliosis, with the goal to identify new strategies to favor CNS repair.

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