Nicolas Degauque
  • E-mail :[email]
  • Phone : +33 2 40 08 46 89
  • Location : Nantes, France
Last update 2024-04-19 11:12:24.115

Nicolas Degauque PhD Transplantation Immunology

Course and current status

EDUCATION AND EMPLOYMENT

10/14 to Pres: CR2TI INSERM1064 (Nantes, France). Position: Researcher CR1

10/10 to 09/14: CRTI INSERM1064 (Nantes, France). Position: Researcher CR2

01/08 to 10/10: INSERM643 (Nantes, France). Training: Senior Postdoctoral Fellow (Mentor Jean-Paul Soulillou)

02/05 to 12/07: BIDMC, Harvard Medical School (Boston, USA). Training: Postdoctoral Fellow (Mentor Terry B Strom)

10/01 to 12/04: INSERM437 (Nantes, France). Training: PhD (Mentor Jean-Paul Soulillou)

RESEARCH FUNDING (2012-Present, Selected from a total of 10 grant awards totalling €1,334,600)

Current

  1. 1.     VISICORT: Adverse Immune Signatures and their Prevention in Corneal Transplantation (WP leader, Co-investigator). Funding Body: European Commission (FP7). Direct Costs : 710k€, 04/14 – 03/19.
  2. 2.     CD8+CD28NEG T cells, a threat to transplantation (Principal Investigator/Coordinator). Funding Body: Labex IGODirect Costs :256k€, 2016-2019
  3. 3.     Define the endothelium damage induced by TEMRA CD8 T cells from kidney transplant recipients (Principal Investigator). Funding Body: CENTAUREDirect Costs : 50k€, 2016-2018
  4. 4.     Dynamic of CD8 T cell selection in blood and biopsy of patients with subclinical intragraft inflammatory infiltrates(Principal Investigator).Funding Body:CENTAUREDirect Costs : 50k€, 2015-2017

Completed

  1. 1.     Projets de recherche translationnelle sur des cohortes et des biotiques(Principal Investigator/Coordinator).Funding Body: ITMO Sant PubliqueDirect Costs : 30k€, 2013-2015
  2. Progreffe International Felllowship (Principal Investigator). Funding Body: CENTAUREDirect Costs : 96k€, 2012-2015
  3. Study of direct alloreactive CD8 T+ cells in the evolution of kidney graft (Principal Investigator). Funding Body: ESOTDirect Costs : 35k€, 2012-2015

HISTORY OF MENTORING AND SUPERVISION (Past/Current):

PhD Students: 3/2. MSc/MD Students: 8/1. Undergrad Students: 6/2. Senior Technicians/Research Associates/Project Managers: 2/2.

COMMERCIALISATION ACTIVITIES: Patents: 1.

KEY ACHIEVEMENTS AND HONOURS:

Mentor-Mentee Award (TTS) 2013; Post-doctoral Fellowship from TTS (Transplantation Society) 2008 -2010; Young Investigator Award (ATC) 2007. Peer Reviewer for >10 Scientific Journals. Invited Lectures (2006-Pres.): 10. Presentations at National/International Meeting as Presenting or Senior Author (2000-Pres.): 22 Oral and 37 Posters.

Scientific summary

My research is dealing with the study of the involvement of CD8 T cells and B cells in transplantation immunology, especially to decipher the immunological mechanisms leading to late chronic transplantation rejection for kidney recipients.Thanks to a close collaboration with the clinical team, we are mainly studying the immune response using biological samples retrieved from transplanted patients.

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