YVES DENIZOT PhD
Course and current status
PhD, aged 51, senior searcher at the Unit CNRS 6101 (University of Limoges, France).
1991-2011 CR INSERM (Institut National de la Santé et de la Recherche Médicale)
1986-1990 PhD, Université Pierre et Marie Curie (Paris VI), France : “Biosynthesis of PAF by eukaryotic and prokaryotic cells : physiopathological consequences »
1985-1986 Master degree of Immunology, Juillet 1986, Institut Pasteur, Paris, France
Scientific summary
The immunoglobulin heavy chain (IgH) locus undergoes multiple changes along B cell differentiation, affecting transcription and accessibility to V(D)J or class switch recombination (CSR). The iEm enhancer upstream of Cm mostly promotes V(D)J recombination. We are working on the role of the 3'IgH regulatory region (3'RR) enhancers (hs3a, hs1,2, hs3b and hs4) located downstream of the IgH C alpha gene during B cell maturation and lymphomagenesis.
We reported that the 3’RR is the master element that controls CSR and sustains high-level transcription at the plasma cell stage. This latter role suggests that the 3’RR may be involved in oncogene deregulation during the frequent IgH translocation events associated with B-cell malignancies. Convincing demonstration of the essential contribution of the 3’RR in lymphomagenesis has been provided by transgenic animal models. The mouse 3’RR shares a strong structural homology with the regulatory regions located downstream of each human Ca gene. Mouse models exploring the role of the 3’RR in B-cell physiology and in malignancies should provide useful indications about the pathophysiology of human cell lymphocyte proliferation.
