Scientific topics
Keywords
ITMO
Yann A. GAUDUEL Director of research - Dr ès sciences - PhD of Biophysics
Course and current status
- Scientific and Medical Educations
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1987 |
HDR equivalence, University of Paris XI, Orsay, France |
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1983 |
Doctorat ès Sciences, Biophysics, University of Paris XI, Orsay, France |
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1977-1983 |
Medical education (PCEM-DCEM2), University of Paris XI, Medical Faculty of Kremlin-Bicêtre, France |
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1978 |
Ph.D. of Biophysics - University of Paris XI, Orsay, France |
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1971-1977 |
Scientific education (DEUG, Master, DEA), University of Maine, University of Rennes, University of Paris XI, Orsay, France |
- Academic and Professional Positions
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2024... |
Member of the International Scientific Council at National Institute of Cancer (INCa, France) http://www.e-cancer.fr/ |
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2016-2022 |
Member of the College of Experts at European Science Foundation (ESF, Brussels) |
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2013-2023 |
Member of the International Scientific Council at National Institute of Cancer (INCa, France) http://www.e-cancer.fr/ |
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2010-2014 |
Member of the European Management Committee COST, Action NanoIBCT (Nanosacle Insights into Ion Beam Cancer Therapy) |
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2006-2022 |
Co-founder and director of Radiation Biophysics MELUSYN network (Medicine and Synchrotron light) - Director of Research 1st Class at INSERM - Head of Low and High Energy Radiation Femtochemistry – Physics-Cancer Interface, LOA, CNRS UMR 7639, Ecole Polytechnique – ENSTA, Palaiseau, France |
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1990-2005 |
Director of Research 2ndClass at INSERM - Founder and Head of Bioradical Femtochemistry Group – LOA – UMR 1406 Ecole Polytechnique – ENSTA, Palaiseau, France |
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1992-2002 |
Co- Founder and Co-coordinator of CNRS Research Network 1017, CNRS Paris, France |
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1983-2001 |
Professor at ENSEA, Cergy Pontoise, France |
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1984-1990 |
Researcher INSERM, U275, LOA, Ecole Polytechnique – ENSTA, Palaiseau, France |
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1981-1983 |
Assistant of biophysics, Medical Faculty of Lariboisière-St Louis, University of Paris VII, France |
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1980-1981 |
Military scientific position, Centre de Défense Nucléaire Biologique et Chimique (CNBC), Vert-le-Petit, France |
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1978-1980 |
Assistant of biophysics, Faculty of medicine Lariboisière-St Louis, University Paris VII, France |
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1976-1978 |
DGRST Research granting, University of Paris XI, Orsay, France |
Short term scientific missions in ESRF (European Synchrotron Radiation Facility, Grenoble, France) Radiation laboratory (Notre Dame University, USA), Bhabha Atomic Research Centre (Mumbai, India), Argonne National Laboratory (USA)
- Teaching Activities
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2010-2014 |
Lecture to Master Radiotherapy : Biological effects of ionizing radiations: relationship between Time, Space and Energy deposition, Gustave Roussy Institute, Villejuif, France Lecture to International Master SERP Chem, University Paris XI, Orsay, France |
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1983-2002 |
Professor at Ecole Nationale Supérieure de l’Electronique et de ses Applications (ENSEA), Cergy Pontoise, France. Fundamental aspects of Laser-matter interaction - Radiation biology and biophysics - Radiodiagnostics |
- · Domains of expertise
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Fundamental sciences |
Ultrafast laser science - Photons and Relativistic particles |
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Ultrafast laser spectroscopies (UV-Infrared) |
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Low and High Energy Radiation Femtochemistry (eV - MeV range) |
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Prethermal processes (classical and quantum phenomena) |
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Computed MD simulations |
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Biomedical sciences |
Spatio-temporal radiation biophysics at molecular and cellular levels |
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Medical physics and advanced radiation sources (ultrashort relativistic particle beams, accelerated ions, synchrotron sources) |
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Advanced concepts for pulsed radio-chemotherapies of cancers |
Scientific summary
The researches of FemtoChemicalBiology Group at LOA (Ecole Polytechnique - ENSTA, Palaiseau) are developed at the interface of fundamental physical chemistry and biomedical sciences, using ultrashort laser facilities and high-time resolved spectroscopic techniques. They concern the innovating domain of Bioradical Femtochemistry for which photo and radio-induced radical events can be investigated at the time scale of small molecular motions, typically in the temporal range 10-13 – 10-11 s. At the international level, femtochemistry has been honoured in 1999 by the Nobel Prize in Chemistry, awarded to Prof. Ahmed Zewail (Caltech University, USA). More recently (2018), Ultrafast laser science has been honoured by the Nobel Prize in Physics, awarded to Prof. Gérard Mourou (former director of LOA, Ecole polytechnique-ENSTA, France).
- · Research developments - Innovating approaches
Since 2003 Implementation and development of High Energy Radiation Femtochemistry (HERF), using TW-laser plasma accelerator and ultra-short particles bunches in the MeV domain. Investigation of prethermal bioradical processes in condensed phase. Transdisciplinary developpement of advanced spatio-temporal radiation biomedicine: new concepts for real-time nanodosimetry, time dependent molecular EBR for normal and cancerous cells, pulsed cancer radiotherapies at high dose rate (NANOBIODOS project supported by AVIESAN and INCa, 2012-2015).
Spatio-temporal radiation biophysics represents a newly emerging interdisciplinary research field driven nowadays in strong synergy with the most recent progresses of molecular biology, genomics and proteomics, biomarker detections, X-ray synchrotron micro-imaging, well-defined spatial irradiation with microbeams, pulsed relativistic particle sources delivered by TW laser-plasma accelerators, selective targeting radiopharmaceutical, advanced radiation therapies of cancers. https://link.springer.com/chapter/10.1007/978-3-319-31563-8_2
MELUSYN network organizes regularly thematic days and transdisciplinary joint meetings. In 2009 it has initiated the organization of an international ESF-EMBO conference entitled “Spatio-Temporal Radiation Biology: Transdisciplinary Advances for Biomedical Applications”. http://archives.esf.org/scientific-support/conferences/conf-list-archives.html?year=2009
A Special Issue devoted to this emerging domain has been published in Mutation Research Reviews (Y.A. Gauduel Ed, 212 pages, 2010) http://sciencedirect.com/science/journal/13835742/704
Previous researches
1984 - 2002 Development of low energy radiation femtochemistry (LERF) in the UV-IR domain and pioneering works on ultrafast dynamics of excited electron and bioradical processes in liquid water, ionic solutions, organized assemblies and biomimetic systems.
1976 – 1984 Biophysical aspects of molecular oxygen activation and oxidative stress during myocardium post-ischemia. Molecular regulation of bioradical and energetic pathways in cardiac tissue.
- · Research valorisation
1984 -1992, collaboration with a cardiac surgery team (Lariboisière hospital, France) for the elaboration of a cardiac transplant preservation process (Cardioplegic Celsior solution). This process has been validated by the Food and Drug Administration (USA) in 1999 and is actually distributed by IGL Group all over the world http://groupe-igl.com/
