Fabrizio Mammano
  • E-mail :[email]
  • Phone : +33 2 47 36 62 86
  • Location : Tours, France
Last update 2021-11-12 12:21:54.58

Fabrizio Mammano PhD, Virology

Course and current status

Current position:

Director of Research at INSERM;

Deputy Director, INSERM Unit 1259 MAVIVH, University of Tours Medical School, France


M.Sc. Nov 1989, (Biology) Faculty of Sciences, University of Padua, Italy

Ph.D. Sept 1994, (Virology) University of Padua Medical School, Italy

HDR Apr 2005 (Habilitation to Direct Research) University Paris Diderot, France

Professional Experience:

2019-21 Director of Research, Host-Pathogen Interactions group, INSERM U1124, Univ of Paris, France

2011-18 Head, Viral Evolution and Pathogenesis group, INSERM U941, Univ/Hosp Saint-Louis, Paris, France

2007-10 Director of Research, Department of Virology, Institut Pasteur, Paris France

1999-2006 Staff Scientist, INSERM U552 Antiviral Research, Univ/Hosp Bichat, Paris, France

1996-98 Post-Doc, Department of Virology, Institut Pasteur, Paris France

1992-96 PhD Student + Post-Doc, Harvard Medical School, Boston MA, USA

1990-92 PhD Student, Institute of Oncology, University of Padua, Italy

Scientific summary

My research focuses on HIV (human immunodeficiency virus) with two main axes: virus replication and virus evolution.

HIV replication. We are interested in the interaction among viral proteins and with cellular partners, required for virus replication. To explore them, we have established in our laboratory specific assays that allow to study individual steps of the virus replication cycle, and the effect of mutations. We also study viral latency (absence of replication), which allows HIV to persist in the reservoirs despite antiviral treatment.

HIV evolution. We have a longstanding interest in the development of HIV resistance to antiretroviral drugs. Our aim was to elucidate the parameters driving the selection of specific drug-resistance mutations in treated patients. In particular, we highlighted the impact of drug-resistance mutation on virus fitness. At present, we explore the impact of type-I interferon on HIV replication and the viral strategies that lead to virus escape, both in vitro and in treated patients.

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