Simona Miron PhD Structural Biology
Course and current status
Simona Miron, 41 years old
MSc of Université Paris 11 (1995)
PhD of Université Paris 11 (1998)
Present situation: Scientist CR1 INSERM at Laboratoire de Biologie Structurale et Radiobiologie (LBSR), SB2SM, CEA, Gif-sur-Yvette, France
Post-doc at Departement of Biophysical Chesmistry, Lund, Sweden (Pr. Mikael Akke) (1999-2000)
Post-Doc at Laboratoire de Biophysique Moléculaire, U350-INSERM, Institut CURIE, Orsay, France (Dr. Constantin Craescu) (2001-2003)
Post-Doc at Centre de Biophysique Moléculaire, Orléans, France (Dr. Jean-Calude Maurizot) (2004)
Scientific summary
The cell machinery requires a complex network of interactions, between different partners, with particular affinities and specificities. The structural and thermodynamic data on molecules of biological interest constitute the molecular basis for the understanding of the cellular functions. A complete understanding of the biological activity of molecules in vivo and the understanding of cellular pathological mechanisms requires a comprehensive description of their functions, by physicochemical and structural analyses, in vitro, in isolated or in simplified environments.
In this respect my research interest is to study the structure-dynamics-function relationship of some proteins (centrins, DNA repair proteins, telomeric proteins) in order to understand their mechanism but also to be able to inhibit their function when necessary. For this purpose I use biochemical and biophysical techniques, as protein engineering, Nuclear Magnetic Resonance (NMR), thermodynamics (ITC), Circular Dichroism, fluorescence and Small Angle X-ray scattering (SAXS) techniques.
