CV Science

Frédéric Causeret PhD Developmental Neurobiology

Course and current status

2018 onwards: Inserm researcher in the team of Alessandra Pierani. Imagine Institute and Institute of Psychiatry and Neurosciences of Paris - France.

2012-2017: Inserm researcher in the team of Alessandra Pierani. Institut Jacques Monod - Paris, France.

2007-2011: Inserm Junior post-doctoral fellow in the team of Alessandra Pierani. Institut Jacques Monod - Paris, France.

2004-2007: EMBO post-doctoral fellow in the team of Margareta Nikolić. Imperial College London - London, UK.

2001-2004: PhD student under the direction of Evelyne Bloch-Gallego. Inserm U106 and Institut Cochin - Paris, France.

Scientific summary

I am interested in understanding the cellular and molecular mechanisms of brain development, especially neuronal fate specification and cell death/survival. In the past I also investigated neuronal migration and axon guidance . I use a wide range of approaches including single-cell RNAseq, mouse genetics, histology, neuronal culture, biochemistry and molecular biology to better understand the signalling pathways involved in these processes and how their disregulations can lead to pathologies.

Past and recent findings:

- Fate specification of Cajal-Retzius cells in the developing cerebral cortex

- Function and evolution of the Dbx1 transcription factor and Dbx1-derived lineages in forebrain development

- Identification of Kremen1 as a dependence receptor controlling cell death/survival

- Involvement of cytoskeletal regulators in axon growth & guidance and neuronal polarity & migration

- Role of secreted guidance factors in the migration and survival of precerebellar neurones

https://orcid.org/0000-0002-0543-4938