CV Science

Jagadeesh Bayry DVM, PhD (Immunology), HDR

Course and current status

2018- Present : Director of Research. A tenured position at Institut National de la Santé et de la Recherche Médicale (INSERM).

2010- 2018:  Chargé de Recherche-CR1/CRCN (Equivalent of Associate Professor). A tenured position at Institut National de la Santé et de la Recherche Médicale (INSERM).

2006-10: Chargé de Recherche-CR2 (Equivalent of Assistant Professor). A tenured position at Institut National de la Santé et de la Recherche Médicale (INSERM).

Additional posts

2016- :  Member of a commission at European Research Council (ERC)

2015:   Scientific Council Member: INNO INDIGO partnership Programme on “Diagnostic and interventions in chronic non-communicable diseases”: Innvovation-driven initiative for the development and integration of Indian and European research (India and Belgium,  Estonia, France, Germany, Norway, Portugal)

Post-doc Research

2006: INSERM U681, Centre de Recherche des Cordeliers, 75006, Paris

2004-2006: University of Oxford, The Edward Jenner Institute for Vaccine Research, UK.

2003-2004: INSERM Unit 430 – Institut Biomedical des Cordeliers, Paris, France.

1999-2000: Poultry Diagnostic and Research Center, Pune, India.

Scientific summary

Maintenance of immune homeostasis is a worthy cause. This process ensures immune tolerance for the self antigens to avert autoimmune diseases, prevents detrimental inflammatory responses following encounter with innocuous antigens, clears altered cells and elicits optimal response to clear pathogens. Immune homeostasis is a complex process implicating the cross-talk between various immune cells and their products. Over the last 18 years, research conducted by my team and myself has been focused on investigating the mechanisms by which CD4⁺CD25⁺FoxP3⁺ regulatory T cells (Tregs), B cells and circulating immunoglobulins maintain immune homeostasis, and exploiting this fundamental knowledge for the translational research. Our research led to unravelling of novel mechanisms by which Tregs, B cells and their products, the immunoglobulins, accomplish immune homeostasis by regulating the dendritic cell and basophil functions, and T cell polarization. These fundamental discoveries were subsequently exploited for translational purposes wherein we provided a “proof of principle” for the efficient targeting of Tregs (without their depletion rather transiently inhibiting their negative influence on the immune system) by small molecule antagonists to CCR4 that exhibited ‘adjuvant’ like properties to enhance immune response to the vaccines. Further, the ability of therapeutic normal immunoglobulin to reciprocally regulate pathogenic Th17 and Tregs in autoimmune conditions provides translational insight and therapeutic utility of circulating normal immunoglobulins in establishing immune tolerance. 

In addition, as secondary research domain, we are  exploring the immune evasion mechanisms of two respiratory pathogens: Aspergillus fumigatus and Mycobacterium tuberculosis.