Last update 2011-04-01 14:46:07.068
Gilles Querat PhD Virology Flavivirus antiviral
Course and current status
1981-1999: Retrovirology: work on animal lentiviruses Visna and CAEV and on D type Jaagsiekte sheep retrovirus: cycle of replication, cloning and sequencing, gene function, pathogenesis.
2000-2005: HIV: reverse transcription and integration; role of cellular UNG2 in viral replication.
2005-present: IRD, UMR 190, Emerging viral disease: Flavivirus (Dengue, West Nile, Yellow Fever).
- Innate immunity (TLR3) escape by flavivirus
- Antiviral research
Scientific summary
Present works:
Hits to Lead optimization of compounds inhibiting viral replication of flaviviruses (clinical/field isolates) in cell cultures.
Chemical library screening of compounds inhibiting Toscana virus (Bunyavirus) in cell cultures
