Scientific topics
Keywords
Anny Slama-Schwok PhD, Biophysicist and drug designer
Course and current status
Dr. Anny SLAMA-SCHWOK
Molecular Virology and Immunology, INRA UR892, Jouy en Josas, France
tel : +33 1 34 65 26 04 ; e-mail : anny.schwok@jouy.inra.fr
http://www.biomedexperts.com/Profile.bme/1319553/Anny_Slama-Schwok
https://www.jouy.inra.fr/vim/content/download/3011/30789/version/2/file/web-VIM.pdf
INSERM researcher, Biophysics and drug design group
Group members: Dr Bogdan Tarus (Post-doc, molecular modelling), Lucie Duchemin (engineer, protein biochemistry), Nathalie Lejal (technician, cell biology)
Keywords: biophysics of proteins & nucleic acids, drug design of chemical activators and inhibitors of proteins.
EDUCATION:
1981 - 1986 Ph.D, Physical Chemistry, Hebrew University of Jerusalem, Israel, supervision Prof. J. Rabani.
1993 Qualification to become professor & HDR (Physical chemistry, speciality Photochimistry)
POSITIONS AND APPOINTMENTS:
1987-1988: Postdoctoral fellow in Biophysics at the Collège de France supervised by Prof. Jean-Marie Lehn and in collaboration with Prof. Claude Helene (MNHN), Paris; development of artificial photonuclease for single-stranded DNA photocleavage
1989-1990: Assistant-Professor at the Hebrew University; engineering of doped sol-gel glasses as new materials to control the rate of photo-induced and back electron transfer (Slama-Schwok et al Nature 1992 355, 240).
1991: Permanent teaching position in France, Maitre de Conference, Université Paris XIII
1993-1997: Scientist of the French institute for medical research INSERM: research focused on the selective recognition and photocleavage of DNA and RNA hairpins (Slama-Schwok et al J. Am. Chem. Soc., 1995, 117, 6822; Nucleic Acids Res. 1997 25 2574).
1998-1999 INSERM Scientist at the laboratory directed by Pierre Douzou and P Debey (1998-1999) research area: protein biophysics
2000-2007: Scientist at INSERM unit of Jean-Louis Martin; ultrafast kinetics studies of the molecular regulations of the NO-synthases by NO, BH4 and nitrite, role of nitrite in hypoxic vasodilation (2006) Biochem. Biophys. Res. Comm. 341 816-821. In parallel, development a new nanotrigger to synchronize and initiate enzymatic catalysis by light-induced electron injection at the NADPH sites of proteins, research in collaboration with Mireille Blanchard-Desce (Rennes) and Pavel Martasek (Prague) (J. Am. Chem. Soc. 2007, 129, 2178-2186).
2008-present: INSERM scientist, Group leader in biophysics and drug design, Influenza A group, INRA unit 892, directed by Bernard Delmas
Area of knowledge : drug design, biophysics, photophysics, and photochemistry, protein- protein and protein- nucleic acids interactions, ultra-fast absorption and fluorescence spectroscopies, pulse radiolysis.
Scientific summary
Rational design of new photoactivable protein activators and inhibitors
Research themes
- Development of new antivirals targeting Influenza A virus proteins, ANR grant 2010 FLUNUCLEOVIR in collaboration with the structural virology group of Rob Ruigrok, Grenoble, and a chemist group and the SPR platform of IECB, S. Quideau and C. di Primo, Bordeaux.
- Development of molecular switches, called nanotrigger, to control NADPH-mediated enzymatic catalysis with biphotonic excitation; use of a nanotrigger applied to NO-synthases to improve hypoxic pathologies. ANR Grant 2008 –TRIGNOSTUMOR, in silico modelling (A. Slama-Schwok & B. Tarus) in collaboration with the biophotonic group of Eric Deprez (ENS Cachan), the chemist groups of Jean-Luc Boucher (Paris Descartes) and Mireille Blanchard-Desce (Rennes) and the vascular biology plateform of the Catholic University of Louvain directed by Chantal Dessy and Olivier Feron (UCL, Belgium).
