CV Science

David Vaudry Proteomic and genomic regulation during neuronal cell death & differentiation

Course and current status

David Vaudry, Ph.D.

Place and date of birth: Harfleur, France, September 8, 1972

Nationality: French

Work address: Neurotrophic factors and neuronal differentiation team, INSERM U982, International Associated Laboratory Samuel de Champlain, Regional Platform for Cell Imaging (PRIMACEN), European Institute for Peptide Research (IFRMP23), University of Rouen,n 76821 Mont-Saint-Aignan, France.

Current position:

• Researcher at the INSERM Institute, October 2002 to date (first class since October 2006)
• Interface contract with University of Rouen (Contract Professor), September 2007 to date.

Degrees:

• Master of Cell Biology in Neurosciences, University of Rouen (1997)
• PhD in Neuroscience, University of Rouen, France (2000)
• Habilitation to Supervise Research in Science, University of Rouen (2004)
• Authorization to Investigate on Animals (2005).

Postdoctoral training:

• Visiting Scientist, Laboratory of Cellular and Molecular Neurosciences, NIMH, NIH, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD, USA, January 2001-September 2002.

Scientific and professional societies or committees:

• French Society of Neurosciences (1999-     )
• French Society of Neuroendocrinology (2001-     ) Member of the scientific committee
• Forum of European Neurosience (1999-     ) 
• International Brain Research Organization (1999-     ).

Distinctions:

• Invited Professor at INRS-Institut Armand-Frappier, Montréal, Canada, 2010-2012.
• Akira Arimura Young Investigator Award, 9^th International Symposium on VIP, PACAP and Related Peptides, Kagoshima, Japon, Octobre 2009.
• Invited Professor at Fudan University (Shanghai), 2008 & 2011.
• Young Investigator award at the 29^th Winter Neuropeptide Conferences, Breckenridge, USA, 2003
• Poster prize award, 5^th Annual Meeting of the French Neuroscience Society, Toulouse, 2001
• Young Investigator award at the XXX^th Annual Meeting of the French Neuroendocrinology Society, Spa, Belgium, 2001
• Travelling award, 5^th Symposium on VIP, PACAP, Secretin, Glucagon and Related Peptide, Santa Barbara, CA, USA, 2001

Peer review activity:

• Peer Reviewer for the following scientific journals: British Journal of Pharmacology, Endocrinology, European Journal of Neuroscience, Experimental Cell Research, Expert Opinion on Biological Therapy, Developmental Brain Research, Journal of Clinical Investigations, Journal of Neurochemistry, Journal of Neuroscience Methods, Journal of Neuroscience Research, Molecular and Cellular Biology, Molecular Pharmacology, Annals of the New York Academy of Sciences, Peptides, PNAS, Regulatory Peptides
• External peer reviewer for the Wellcome Trust in 2004, ANR & AERES  in 2010
• Guess Editor for a special issue of Regulatory Peptides in 2006.

Scientific animation:

• Organizer of a Workshop on cell imaging in May 2003 at the University of Rouen.
• Organizer of an INSERM  Workshop on microscopy in October 2004 at the University of Rouen
• Member of the Local Organizing Committee of the French Society of Microscopy congress that was held in Caen in July 2005
• Member of the Local Organizing Committee of the 7^th International Symposium on VIP, PACAP and Related Peptides that was held in Rouen in September 2005
• Co-organizer with Dr Youssef Anouar and Lee Eiden of a Workshop on genomic and proteomic that was held in Mont-Saint-Aignan in September 2005
• Organizer of an INSERM Workshop on real time PCR in May 2006 at the University of Rouen
• Coordinator of the research team “Neurotrophic Factors and Neuronal Differentiation” since 2007
• Organizer of a Workshop on cell imaging and proteomic novelties in March 2007 at the University of Rouen
• Organizer of an INSERM Workshop on microdissection and real time PCR in November 2007, June 2009 and September 2009 at the University of Rouen
• Organizer of a  Workshop to present the technical facilities of the IFRMP23 in September 2009 at the University of Rouen
• Member of the Local Organizing Committee of the 7^th International Congress of Neuroendocrinology that was held in Rouen in July 2010.

Supervision of PhD and post-doc students:

• October 2003 - October 2007 : Aurélia Ravni, PhD student
• October 2004 - June 2009: Valérie Jolivel, PhD student
• October 2004 - June 2009: Steve Bourgault, PhD student
• October 2005- September 2009: Béatrice botia, PhD student
• July 2006 - July 2008: Dr Agnieszka Dejda, post-doc
• November 2007 -  2009: Dr Tommy Seaborn, post-doc.
• October 2009 - : Mlle Brifault, PhD student
• October 2010 - : Mlle Hamza, PhD student

Teaching:

         I have started by teaching confocal microscopy at Master students in 1999. I am currently responsible for several courses at the University of Rouen (28 hours of teaching per year).

Technical skills:

Cell culture, Confocal microscopy, Histology, HPLC, Microarray, Microplate reader, Northern and Western blotting, Proteomic analysis, Quantitative RT-PCR, Radioimmunoassay, Retrovirus vectors, siRNA, Time laps microscopy.

Scientific summary

I joined the Laboratory of Cellular and Molecular Neuroendocrinology in 1996 to investigate the neurotrophic effects of PACAP in the developing cerebellum. In 2000, I received a PhD from the University of Rouen under the supervision of Dr Bruno Gonzalez and went for a post-doc in the laboratory of Dr Lee Eiden at the National Institute of Mental Health in Bethesda to investigate the genes regulated by PACAP during PC12 cell differentiation and to characterize the cerebellum of PACAP knock-out mice. In 2002, I was appointed as an INSERM Researcher on a project focusing on the functional evaluation of genes and proteins involved in the neurotrophic effects of PACAP. More recently, I started to develop in collaboration with the team of Pr Alain Fournier, PACAP analogs with improved plasma stability and higher selectivity towards the PAC1 receptor for possible future therapeutic applications. I am currently group leader in INSERM Unit 982 within the European Institute for Peptide Research (IFRMP23). Our research team now investigates the effects of several factors on cell death and differentiation either during development or in stroke models. My research projects are supported by grants from INSERM, the Agence Nationale de la Recherche (ANR), the Fondation pour la Recherche Médicale (FRM), the Institut de Recherches Scientifiques sur les Boissons (IREB), the Institut pour la Recherche sur la Moelle épinière et l’Encéphale (IRME) and the European Regional Development Fund (ERDF). I have published 62 research papers on PACAP including 2 comprehensive reviews in Pharmacological Reviews (2000, 2009), 2 Sciences (2002, 2003), 4 PNAS (1999, 2000, 2002, 2005), 1 Molecular Pharmacology, 5 Journal of Neurochemistry (2002, 2004, 2006, 2006, 2009), 4 Neuroscience (1997,1998, 2007, 2009), 3 J Comp Neurol (2000, 2002, 2007) and 1 J Med Chem (2009). My papers on PACAP have already received over 2650 citations