Emmanuelle Comets PhD in Biomathematics

Course and current status

Current position (since 2002): Researcher at INSERM, National Institute of Health and Medical Research, France

2002-present: Researcher (CR1), INSERM UMR 738, Bichat Hospital, Paris, France

2000-2002: Post-doctorate fellow, Keio University Hospital, Tokyo, Japan

1997-2000: PhD in Biomathematics, University Pierre et
Marie Curie, Paris VI, France (Supervisor: Pr France Mentré, Topic: PK/PD model of long-acting release formulations of octreotide)

1994-1996: Ingénieur en Agronomie, Institut National Agronomique Paris Grignon, France

1991-1994: Ingénieur de l'Ecole Polytechnique, Ecole Polytechnique, Palaiseau, France

Scientific summary

My area of research consists in developing mathematical and statistical models to describe the dose-concentration-response relationships of drugs. This area of research has become known recently as Pharmacometrics.

I work mostly on longitudinal data, using nonlinear mixed effect models to describe the time-course of the observed processes. My main methodological developments concern the building and evaluation of these models, with a particular emphasis on pharmacogenetics. I'm also interested in design optimisation and algorithms for parameter estimation.

My daily work includes applying these approaches to data from clinical or experimental trials, in particular in the area of anticoagulant drugs, haematology, cancer and rheumatology.

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