CV Science

Laurent Dubuquoy PhD Immunology

Course and current status

A. Personal Statement

I was graduated in Biology at the Université Lille 1 in 1998. In 1999 I started my PhD in the Inserm E0114, Lille University Hospital, under the supervision of Dr Pierre Desreumaux. During my PhD I was mainly involved in developing new therapeutic target in inflammatory bowel diseases. I obtained my PhD degree at Université Lille 2 in 2002. During this period I had the opportunity to move in the Center of Genomic Research, Karolinska Institutet, Stockohlm, Sweden, for a training period. I improved my technical skills in Molecular Biology under the supervision of Sven Petersson. From 2003 I moved to the Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, headed by Prof. Pierre Chambon. During this postdoctoral period I developed experimental models to study the role of nuclear receptor in digestive disease (gut and liver) under supervision of Dr Johan Auwerx. From 2006 I moved back to Lille in Inserm U995/Lille University Hospital where I have developed projects to explore pathophysiological role of the gut-liver axis with Dr Philippe Mathurin. From 2009 I have been working on translational approaches to explore pathophysiological mechanisms of alcoholic hepatitis. We have observed that severe forms of alcoholic hepatitis are a complex balance between liver inflammation, cell death, tissue repair and liver regeneration.

B. Positions and Honors

Positions and Employment

1996-1998 Undergraduate student, Department of Cellular Biology and Physiology; Université Lille 1, France

1999-2002 PhD student, Inserm E0114, Hepatogastroenterology department Lille University Hospital.

2001 Visiting fellow, Center of Genomic Research. Karolinska Institutet, Stockohlm, Sweden

2003-2005 Postdoctoral Researcher, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France

2006- Researcher Inserm U995, Lille University Hospital

Honors and Awards

1999-2000 Fellowship from Association François Aupetit

2000 Master award from Gastroentérologie Clinique et Biologique / GlaxoWellcome.

2000-2001 Fellowship from Institut de Recherche sur les Maladies de l’Appareil Digestif (IRMAD)

2001-2002 Fellowship from Fondation pour le Recherche Médicale

2002 Young investigator Award from the Société Nationale Française de Gastro-Entérologie.

2003-2005 Postdoctoral fellowship from Inserm

2009 Walbaum award from Association pour l’Etude des Anomalies Congénitales.

Scientific summary

I have focussed my research on deciphering pathophysiology of inflammatory digestive disease. First I have explored the role of nuclear receptors in pathogenesis and treatment of inflammatory bowel disease. Then I was interested in the gut-liver axis by exploring the two-ways dialog involving PAMPs coming from gut and interfering with liver inflammation and by understanding how liver inflammation could regulate inflammatory process in the gut. More recently I have focussed on liver disease and more particularly on pathogenesis of alcoholic hepatitis to show an essential role of liver regeneration.

To perform this research I have used a wide range of tools such as cellular and molecular biology, animal models, human samples, biochemistry, histology and immunohistochemistry...