Scientific topics
Keywords
ITMO
Anne-Louise Leutenegger Ph.D. Biostatistics - Statistical Genetics
Course and current status
Current Positions
2026- : Head of High-dimensional Biostatistics team (HiDiBiostat) at Inserm CESP-Centre for Epidemiology and Population Health (U1018), Hopital Paul Brousse/UParis Saclay, Villejuif. Jointly with Pascal Tubert-Bitter.
2025- : Associated researcher, Inserm GenoVasc team, ICM, Paris
Past Positions
2024: Senior Research position (CRHC) at Inserm - the French National Institute of Health and Medical Research
2019-2025: NeuroDiderot (U1141), Inserm, Hopital Robert Debré/UParis Cité, Paris. Head of StatGen group: statistical method developments for genomics.
2009-2018: Genetic Variation and Human Diseases Lab (U946), Inserm, CEPH-Fondation Jean Dausset/UParis Cité, Paris. Contribution of population genetics to the study of human diseases: statistical developments for mapping disease genes in isolated and consanguineous populations.
2006-2009: Genetic Epidemiology and Human Population Structure Lab (U535), Inserm, Hopital Paul Brousse/UParis Sud, Villejuif. Genetic component of human diseases in consanguineous populations.
2006: Tenured research position (CRCN/CR1) at Inserm - the French National Institute of Health and Medical Research
2003-2006: Post-doc, Central Nervous System Disorders Lab (U679), Inserm, Hopital Pitié-Salpétrière/UPMC, Paris. Mapping genes involved in neurodegenerative disorders using consanguineous populations.
1998-2001: Research assistant, dept. Biostatistics and Medicine, Univ of Washington, Seattle, USA. Segregation analysis of dyslexia, Linkage analysis of sib-pairs affected with autism.
1997-1998: Teaching assistant, dept. of Statistics, Biostatistics & Center for Quantitative Science, Univ of Washington, Seattle, USA.
Education
2024 : HDR Genomics & Human diseases - UParis Cité (FR)
2003: Ph.D. in Biostatistics, emphasis in Statistical Genetics - jointly between Univ of Washington & UParis Sud. Co-advisors: Elizabeth Thompson (UW), Françoise Clerget-Darpoux (Inserm). Title: Estimation of random genome sharing; consequences for linkage detection
1998: M.S. in Biostatistics - U of Washington (Seattle, USA)
1997: Paris School of Statistics, Economics & Finance - ENSAE (FR)
1995: Maîtrise in Applied Mathematics & Social Sciences - UParis Dauphine (FR)
Boards
2020-present: Scientific advisory board of Inserm workshops
2017-2021: Scientific advisory board of Inserm
2012-2016: Evaluation/recruitment committees of Inserm: Public Health (CSS9), Research Support (CAR)
2011-present: Editorial board of Genetic Epidemiology, https://onlinelibrary.wiley.com/journal/10982272
Awards
Inserm Post-doctoral Fellow (2004-2006)
Thesis award from the French Biometrics Society (2004)
Burroughs Wellcome Fellow / Program in Mathematics and Molecular Biology (2002, 2003)
Scientific summary
My research interests lie at the interface of biostatistics, genetic epidemiology and population genetics. The aim of my research is to identify the genetic basis of human trait/disease by using statistical methods and analysing genomic data from families and populations. My work is mainly focused on neuroscience applications.
My methodological projects are structured around 2 main axes: the contribution of population genetics to medical genetics, and a more recent axis on the study of large-scale data, typically data from general population or medical biobanks (several hundred thousand participants).
In terms of applications, my work has helped to identify and better understand the genetic basis of several diseases, such as neurodevelopmental disorders (autism, microcephalic syndrome, anencephaly), neurodegenerative diseases (Parkinson's disease, spino-cerebellar degenerations, amyotrophic lateral sclerosis) and, more recently, neurovascular diseases (CADASIL, fetal intracerebral haemorrhage).
