CV Science

Richard MOREAU MD, Senior Scientist at the National (French) Institute of Health (Inserm)

Course and current status

ORCID ID: orcid.org/0000-0003-0862-403X

ResearcherID: N-2197-2017

 Current Positions:

1) Director of the European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain

2) Emeritus Senior Scientist at the INSERM (French NIH)

3) Consultant in Hepatology, Liver Unit, Beaujon Hospital (Head Prof F Durand), Assistance Publique Hôpitaux de Paris (APHP), Clichy, France

Current affiliations:

1) European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain

2) Centre de Recherche sur l’Inflammation CRI, INSERM and Université Paris Cité, Paris, France

3) Service d'hépatologie, Hôpital Beaujon APHP, Clichy, France

 

Degree:

1983: MD, University of Paris

Post-Military Position

Member "Club des Chefs de Section Parachutistes au Feu"

Academic Positions: 

• 2019-Date: Emeritus Senior Scientist at the INSERM
• 2014-2018: Senior Scientist: “Directeur de Recherche de Classe exceptionnelle (DRCE)" at the INSERM
• 2009-2013: Senior Scientist: "Directeur de Recherche de 1ere classe" at the INSERM
• 1996-2008: Senior Scientist: "Directeur de Recherche de 2eme classe" at the INSERM
• 2013-2020: Co-Chairman, with Prof. Shiv Sarin (Institute of Liver and Biliary Sciences, ILBS, New Delhi, India) of an International Associated Laboratory entitled “ILBS Associated Laboratory for the Development of Indo-French Research on Severe Liver Diseases”
• 2014-2020: Adjunct Professor, Institute of Liver and Biliary Sciences, ILBS, New Delhi, India
• 2014-2018: Vice-Chairman, Centre de Recherche sur l’Inflammation CRI, UMR_S1149, Inserm and Université Paris-Diderot, Paris 7, Clichy/Paris, France.
• 2013: Chairman, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, UMR_S 773, Inserm and Université Paris-Diderot, Paris 7, Clichy/Paris.
• 2005-2018: Head of Team (Complications of cirrhosis) at the Centre de Recherche Biomédicale Bichat-Beaujon CRB3, UMR_S 773, Inserm and Université Paris-Diderot, Paris 7, Clichy/Paris, France.
• 1996-2004: Head of group in the Lebrec’s lab (successively in Inserm Units 24 and 481), Clichy, France

 

Hospital Positions:

• 1996-2021: Consultant in Hepatology, Liver Unit, Beaujon Hospital (successively Headed by Profs J-P Benhamou, S Erlinger, D Valla, and F Durand), Assistance Publique Hôpitaux de Paris (APHP), Clichy, France
• 1984-2016: Team member of the "Laboratoire d'Hémodynamique Splanchnique et Systémique"; has personnaly performed 2000 transjugular liver biopsies and 500 right heart catheterization.
• 1983-1996: Physician in Intensive Care Units of Ile-de-France 

Other Positions

• 2022-2023: Honorary Director, Grifols Chair, European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain
• 2016-2021: Deputy Director, Grifols Chair, European Foundation for the Study of Chronic Liver Failure (EF CLIF)
• 2009-2018: Member of the Steering Comittee of the Consortium EASL-CLIF (for Chronic Liver Failure); Principal Investigator of the CANONIC Study on Acute-on-Chronic Liver Failure.
• 2009: Founding member of the EASL-CLIF (Chronic Liver Failure) Consortium
• 2010-2013: Member of the SC of the Special Interest Group on Portal Hypertension of the American Association for the Study of Liver Diseases

Scientific Society Membership: 

• American Association for the Study of Liver Diseases (AASLD)
• European Association for the Study of the Liver (EASL)
• Asian Pacific Association ofr the Study of the Liver (APASL)
• French Speaking Society of Intensive Care Medicine
• French Association of the Study of the Liver
• International Ascites Club (Scientific Committee, 1994-2003)
• French Club for the Study of Portal Hypertension

Awards:

• 2009: Colombian Socitety of Gastroenterology
• 2014: Award Scientific Excellence (Inserm)
• 2015: Czech Society for the Study of the Liver
• 2019: “Special Price” by the Club Francophone de l’Etude de l’Hypertension Portale
• 2022: Fellow of the American Association for the Study of Liver Diseases (AASLD)

Editorial Activities:

Boards of Editors

• 2020-21: Special Section Editor, Journal of Hepatology
• 2015-2019: Senior Editor, Journal of Hepatology 
• 2010-2014: Associate Editor, Journal of Hepatology
• 2007-September 2009: Associate Editor, Liver International
• 2001-2008: Co-Editor: Gastroentérologie Clinique et Biologique
• 1997-2001: Associate Editor, Gastroentérologie Clinique et Biologique

 

Editorial Boards

• 2020-2022: Editorial Board, Gastroenterology
• 2011-2014: Editorial Board, Hepatology
• 2007-2009: Editorial Board, Journal of Hepatology
• 2002-2006: Editorial Board, Hepatology

 

French Organization of Research:

• 2008-Date: Expert (Liver Branch) at the Aviesan Institute 'Pathophysiology, Metabolism, Nutrition' (Head, Prof C. Boitard).
• 2010-2017: Elected as Member of the Council advising the Dean of the Faculty of Medicine, University Paris Diderot, Paris  
• 2013-2018: Member of the Steering Committee (SC) of the 'Département Hospitalo-Universitaire' (DHU) UNITY (for Addressing Unmet Needs through Innovation in HepaTology and GastroenterologY), Beaujon Hospital, APHP, Clichy
• 2012-Date: Partner of the 'Laboratoire d’excellence (Labex)' Inflamex, ComUE Sorbonne Paris Cité, Paris. 

Scientific Production:

• 431 Peer-Reviewed publications (PubMed, updated June 2024), including 268 Original Articles, 163 Review Articles or Editorials; h-index: 87 by Web of Sciences, Clarivate Analytics; h-index: 91 by Scopus; h-index: 107 by Google Scholar; SIGAPS (French index): 6588 (1995-Date).
• Editor of 1 book
• 35 book chapters,
• 300 Invited lectures in the context of EASL, AASLD, APASL, ALEH (Latin American Association for the Study of the Liver), International Association for the Study of the Liver (IASL), and National Societies for the Study of the Liver including the Argentinian, British, Belgian, Canadian, Chinese, Columbian, Czech, French, German, Hungarian, Korean, and Swiss societies. 

Representative publications (past 10 years)

1. Cao Z, Yao Y, Cai M, Zhang C, Liu Y, Xin H, An B, Wang H, Lu Y, Li Z, Chen Y, Huang Y, Xin M, Li R, Qian Z, Zhou Y, Xiang X, Moreau R, Xie Q. Blood markers for type-1,-2, and -3 inflammation are associated with severity of acutely decompensated cirrhosis. J Hepatol. 2024 Oct 25:S0168-8278(24)02649-7. PMID: 39490592
2. Clària J, Aguilar F, Lozano JJ, Jiménez-Gracia L, Nieto JC, Romero-Grimaldo B, Marcos-Fa X, Giarracco E, Weiss E, Trebicka J, Hernàndez I, Fernandez J, Casulleras M, López-Vicario C, Muldur S, Hopke A, Vlagea A, Aransay AM, Marchese D, Bernardi M, Jalan R, Angeli P, Magri G, Cerutti A, Irimia D, Heyn H, Arroyo V, Moreau R. Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis.JHEP Rep. 2024 Aug 8;6(11):101184. doi:  10.1016/j.jhepr.2024.101184. eCollection 2024 Nov.PMID: 39434891
3. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on acute-on-chronic liver failure. J Hepatol. 2023 Apr 28:S0168-8278(23)00244-1. doi: 10.1016/j.jhep.2023.04.021. Online ahead of print. PMID: 37364789.
4. Farias AQ, Vilalta AC, Zitelli PM, Pereira G, Goncalves LL, Torre A, Diaz JM, Gadano AC, Mattos AZ, Mendes LSC, Alvares-da-Silva MR, Bittencourt PL, Benitez C, Couto CA, Mendizabal M, Toledo CL, Mazo DF, Barradas MC, Uson Raposo EM, Padilla-Machaca PM, Lozano Miranda AZ, Malé-Velázquez R, Lyra AC, Dávalos-Moscol MB, Pérez Hernandez JL, Ximenes RO, Silva GF, Beltrán-Galvis OA, González Huezo MS, Bessone F, Rocha TDS, Fassio E, Terra C, Marín JI, Casas PS, Peña-Ramirez C, Parera FA, Fernandes F, da Penha Zago-Gomes M, Méndez-Guerrero O, Marciano S, Mattos AA, Oliveira JC, Guerreiro GTS, Codes L, Arrese M, Nardelli MJ, Silva MO, Palma-Fernandez R, Alcantara C, Garrido CS, Trebicka J, Gustot T, Fernández J, Clària J, Jalan R, Angeli P, Arroyo V, Moreau R, Carrilho FJ; ACLARA Study collaborators. Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America. Gastroenterology. 2023 May 30:S0016-5085(23)00806-5. doi: 10.1053/j.gastro.2023.05.033. Online ahead of print. PMID:37263305
5. Weiss E, de la Peña-Ramirez C, Aguilar F, Lozano JJ, Sánchez-Garrido C, Sierra P, Martin PI, Diaz JM, Fenaille F, Castelli FA, Gustot T, Laleman W, Albillos A, Alessandria C, Domenicali M, Caraceni P, Piano S, Saliba F, Zeuzem S, Gerbes AL, Wendon JA, Jansen C, Gu W, Papp M, Mookerjee R, Gambino CG, Jiménez C, Giovo I, Zaccherini G, Merli M, Putignano A, Uschner FE, Berg T, Bruns T, Trautwein C, Zipprich A, Bañares R, Presa J, Genesca J, Vargas V, Fernández J, Bernardi M, Angeli P, Jalan R, Claria J, Junot C, Moreau R, Trebicka J, Arroyo V. Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET). Gut 2023 Feb 14:gutjnl-2022-328708. doi: 10.1136/gutjnl-2022-328708. Online ahead of print.PMID: 36788015
6. Arroyo V, Moreau R, Jalan R. Acute-on-Chronic Liver Failure. N Engl J Med. 2020 May 28;382(22):2137-2145.
7. Weiss E, de la Grange P, Defaye M, Lozano JJ, Aguilar F, Hegde P, Jolly A, Moga L, Sukriti S, Agarwal B, Gurm H, Tanguy M, Poisson J, Clària J, Abback PS, Périanin A, Mehta G, Jalan R, Francoz C, Rautou PE, Lotersztajn S, Arroyo V, Durand F, Moreau R. Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF. Front Immunol 2021 Feb 5;11:619039.PMID: 33613548.
8. Arroyo V*, Angeli P*, Moreau R*, Jalan R*, Claria J, Trebicka J, Fernández J, Gustot T, Caraceni P, Bernardi M; investigators from the EASL-CLIF Consortium, Grifols Chair; European Foundation for the Study of Chronic Liver Failure (EFClif). The Systemic Inflammation Hypothesis: Towards a New Paradigm of Acute Decompensation and Multiorgan Failure in Cirrhosis. J Hepatol. 2020 PMID: 33301825. *Co-first authors
9. Zaccherini G, Aguilar F, Caraceni P, Clària J, Lozano JJ, Fenaille F, Castelli F, Junot C, Curto A, Formentin C, Weiss E, Bernardi M, Jalan R, Angeli P, Moreau R, Arroyo V. Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF. J Hepatol. 2020 Dec 1:S0168-8278(20)33821-6. doi: 10.1016/j.jhep.2020.11.035. Online ahead of print. PMID: 33276029.
10. Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jansen C, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Jarcuska P, Steib C, Reiberger T, Acevedo J, Gatti P, Shawcross DL, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Danielsen KV, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solé C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Kani HT, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia-Lopez E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Praktiknjo M, Curto A, Pitarch C, Putignano A, Moreno E, Bernal W, Aguilar F, Clària J, Ponzo P, Vitalis Z, Zaccherini G, Balogh B, Gerbes A, Vargas V, Alessandria C, Bernardi M, Ginès P, Moreau R, Angeli P, Jalan R, Arroyo V; PREDICT STUDY group of the EASL-CLIF CONSORTIUM. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis. J Hepatol. 2020 Nov 20:PMID: 33227350.
11. Casulleras M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E, López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P, Moreau R, Arroyo V, Clària J. Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis. Sci Transl Med. 2020 Oct 21;12(566):eaax5135.
12. Moreau R, Clària J, Aguilar F, Fenaille F, Lozano J, Junot C, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldasarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin N, Hautbergue T, Cholet S, Castelli F, Jansen C, Steib C, Campion D, Mookerjee R, Rodríguez-Gandía M, Soriano G, Durand F, Benten D, Bañares R, Stauber RE, Gronbaek H, Coenraad MJ, Ginès P, Gerbes A, Jalan R, Bernardi M, Arroyo V, Angeli P; CANONIC Study Investigators of the EASL Clif Consortium, Grifols Chair and the European Foundation for the Study of Chronic Liver Failure (EF Clif). Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF. J Hepatol. 2019 Nov 25. PMID:31778751.
13. Fernández J, Angeli P, Trebicka J, Merli M, Gustot T, Alessandria C, Aagaard NK, de Gottardi A, Welzel TM, Gerbes A, Soriano G, Vargas V, Albillos A, Salerno F, Durand F, Bañares R, Stauber R, Prado V, Arteaga M, Hernández-Tejero M, Aziz F, Morando F, Jansen C, Lattanzi B, Moreno C, Campion D, Gronbaek H, Garcia R, Sánchez C, García E, Amorós A, Pavesi M, Clària J, Moreau R, Arroyo V. Efficacy of Albumin Treatment for Patients with Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis. Clin Gastroenterol Hepatol. 2019 Aug 5.  PMID: 31394283.
14. Fernández J, Clària J, Amorós A, Aguilar F, Castro M, Casulleras M, Acevedo J, Duran-Güell M, Nuñez L, Costa M, Torres M, Horrillo R, Ruiz-Del-Árbol L, Villanueva C, Prado V, Arteaga M, Trebicka J, Angeli P, Merli M, Alessandria C, Aagaard NK, Soriano G, Durand F, Gerbes A, Gustot T, Welzel TM, Salerno F, Bañares R, Vargas V, Albillos A, Silva A, Morales-Ruiz M, Pavesi M, Jalan R, Bernardi M, Moreau R, Páez A, Arroyo V. Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis. Gastroenterology. 2019 Jul;157(1):149-162.
15. Trebicka J, Amoros A, Pitarch C, Titos E, Alcaraz-Quiles J, Schierwagen R, Deulofeu C, Fernandez-Gomez J, Piano S, Caraceni P, Oettl K, Sola E, Laleman W, McNaughtan J, Mookerjee RP, Coenraad MJ, Welzel T, Steib C, Garcia R, Gustot T, Rodriguez Gandia MA, Bañares R, Albillos A, Zeuzem S, Vargas V, Saliba F, Nevens F, Alessandria C, de Gottardi A, Zoller H, Ginès P, Sauerbruch T, Gerbes A, Stauber RE, Bernardi M, Angeli P, Pavesi M, Moreau R, Clària J, Jalan R, Arroyo V. Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis. Front Immunol. 2019 Mar 19;10:476. PMID: 30941129.
16. Clària J*, Moreau R*, Fenaille F, Amorós A, Junot C, Gronbaek H, Coenraad MJ, Pruvost A, Ghettas A, Chu-Van E, López-Vicario C, Oettl K, Caraceni P, Alessandria C, Trebicka J, Pavesi M, Deulofeu C, Albillos A, Gustot T, Welzel TM, Fernández J, Stauber RE, Saliba F, Butin N, Colsch B, Moreno C, Durand F, Nevens F, Bañares R, Benten D, Ginès P, Gerbes A, Jalan R, Angeli P, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL Clif Consortium Grifols Chair and the European Foundation for the Study of Chronic Liver Failure (EF Clif). Orchestration of Tryptophan-Kynurenine pathway, acute decompensation and acute-on-chronic liver failure in cirrhosis. Hepatology. 2019 Apr;69(4):1686-1701. *Co-first authors
17. Moreau R, Elkrief L, Bureau C, Perarnau JM, Thévenot T, Saliba F, Louvet A, Nahon P, Lannes A, Anty R, Hillaire S, Pasquet B, Ozenne V, Rudler M, Ollivier-Hourmand I, Robic MA, d'Alteroche L, Di Martino V, Ripault MP, Pauwels A, Grangé JD, Carbonell N, Bronowicki JP, Payancé A, Rautou PE, Valla D, Gault N, Lebrec D; NORFLOCIR Trial Investigators. Effects of Long-term Norfloxacin Therapy in Patients with Advanced Cirrhosis. Gastroenterology. 2018 Dec;155(6):1816-1827.e9. 
18. Gustot T, Moreau R. Acute-on-Chronic Liver Failure vs. Traditional Acute Decompensation of Cirrhosis. J Hepatol. 2018 Sep 6. PMID:30195459.
19. Maras JS, Das S, Sharma S, Shasthry SM, Colsch B, Junot C, Moreau R*, Sarin SK*. Baseline urine metabolic phenotype in patients with severe alcoholic hepatitis and its association with outcome. Hepatol Commun. 2018 Apr 16;2(6):628-643. PMID:29881815. *Co-senior authors
20. Hegde P, Weiss E, Paradis V, Wan J, Mabire M, Sukriti S, Rautou PE, Albuquerque M, Picq O, Gupta AC, Ferrere G, Gilgenkrantz H, Kiaf B, Toubal A, Beaudoin L, Lettéron P, Moreau R, Lehuen A, Lotersztajn S. Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver. Nat Commun. 2018 Jun 1;9(1):2146. 
21. Bajaj JS, Moreau R, Kamath PS, Vargas HE, Arroyo V, Reddy KR, Szabo G, Tandon P, Olson J, Karvellas C, Gustot T, Lai JC, Wong F. Acute-on-Chronic Liver Failure: Getting ready for prime-time. Hepatology. 2018 Apr 24.PMID:29689120.
22. Sharma S, Maras JS, Das S, Hussain S, Mishra AK, Shasthry SM, Sharma CB, Weiss E, Elkrief L, Rautou PE, Gilgenkrantz H, Lotersztajn S, Paradis V, de la Grange P, Junot C, Moreau R, Sarin SK. Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness. Sci Rep. 2017 Jul 28;7(1):6816. PMID:28754919.
23. Rolas L, Boussif A, Weiss E, Lettéron P, Haddad O, El-Benna J, Rautou PE, Moreau R, Périanin A. NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation. Gut. 2017 Jun 10. PMID:28601846
24. Markwardt D, Holdt L, Steib C, Benesic A, Bendtsen F, Bernardi M, Moreau R, Teupser D, Wendon J, Nevens F, Trebicka J, Garcia E, Pavesi M, Arroyo V, Gerbes AL. Plasma Cystatin C is a predictor of renal dysfunction, ACLF and mortality in patients with acutely decompensated liver cirrhosis. Hepatology. 2017 May 25. PMID:28545169
25. Weiss E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C, Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D, Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C, Lotersztajn S, Moreau R. Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome. J Hepatol. 2016 Dec 28. PMID:28040548
26. Hernaez R, Solà E, Moreau R*, Ginès P*. Acute-on-chronic liver failure: an update. Gut. 2017 Jan 4. pii: gutjnl-2016-312670. PMID:2805305. *Equally contributed
27. Arroyo V, Moreau R. Diagnosis and prognosis of acute on chronic liver failure (ACLF) in cirrhosis. J Hepatol. 2016 Dec 15. PubMed PMID: 27989380.
28. Clària J, Arroyo V, Moreau R. The Acute-on-Chronic Liver Failure Syndrome, or When the Innate Immune System Goes Astray. J Immunol. 2016 Nov 15;197(10):3755-3761. Review. 
29. Clària J, Stauber RE, Coenraad MJ, Moreau R, Jalan R, Pavesi M, Amorós À, Titos E, Alcaraz-Quiles J, Oettl K, Morales-Ruiz M, Angeli P, Domenicali M, Alessandria C, Gerbes A, Wendon J, Nevens F, Trebicka J, Laleman W, Saliba F, Welzel TM, Albillos A, Gustot T, Benten D, Durand F, Ginès P, Bernardi M, Arroyo  V; CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (EF-CLIF). Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure. Hepatology. 2016 Oct;64(4):1249-64. 
30. Poisson J, Lemoinne S, Boulanger C, Durand F, Moreau R, Valla D, Rautou PE. Liver sinusoidal endothelial cells: physiology and role in liver diseases. J Hepatol. 2016 Jul 13. pii: S0168-8278(16)30333-6. 
31. Arroyo V, Moreau R, Kamath PS, Jalan R, Ginès P, Nevens F, Fernández J, To U, García-Tsao G, Schnabl B. Acute-on-chronic liver failure in cirrhosis. Nat RevDis Primers. 2016 Jun 9;2:16041. 
32. Moreau R. The Pathogenesis of ACLF: The Inflammatory Response and Immune Function. Semin Liver Dis. 2016 May;36(2):133-40. 
33. Jalan R, Moreau R, Kamath PS, Arroyo V. Acute-on-Chronic Liver Failure: A Distinct Clinical Condition. Semin Liver Dis. 2016 May;36(2):107-8. 
34. Li H, Chen LY, Zhang NN, Li ST, Zeng B, Pavesi M, Amorós À, Mookerjee RP, Xia Q, Xue F, Ma X, Hua J, Sheng L, Qiu DK, Xie Q, Foster GR, Dusheiko G, Moreau R, Gines P, Arroyo V, Jalan R. Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B. Sci Rep. 2016 May 5;6:25487. 
35. Elkrief L, Rautou PE, Sarin S, Valla D, Paradis V, Moreau R. Diabetes mellitus in patients with cirrhosis: clinical implications and management. Liver Int. 2016 Jul;36(7):936-48. 
36. Boussif A, Rolas L, Weiss E, Bouriche H, Moreau R, Périanin A. Impaired intracellular signaling, myeloperoxidase release and bactericidal activity of neutrophils from patients with alcoholic cirrhosis. J Hepatol. 2016 May;64(5):1041-8. 
37. Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS. Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. J Hepatol. 2016 Mar;64(3):717-35. 
38. Nahon P, Lescat M, Layese R, Bourcier V, Talmat N, Allam S, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP,  Goria O, Calès P, Péron JM, Alric L, Bourlière M, Mathurin P, Blanc JF, Abergel A, Serfaty L,  Mallat A, Grangé JD, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Hillaire S, Di Martino V, Trinchet JC, Moreau R, Roudot-Thoraval F; ANRS CO12 CirVir and Microcir Groups. Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospectivecohort). Gut. 2015 Oct 28. pii: gutjnl-2015-310275. doi: 10.1136/gutjnl-2015-310275. PubMed PMID: 26511797.
39. Sarin SK, Kedarisetty CK, Abbas Z, Amarapurkar D, Bihari C, Chan AC, Chawla YK, Dokmeci AK, Garg H, Ghazinyan H, Hamid S, Kim DJ, Komolmit P, Lata S, Lee GH, Lesmana LA, Mahtab M, Maiwall R, Moreau R, Ning Q, Pamecha V, Payawal DA, Rastogi A, Rahman S, Rela M, Saraya A, Samuel D, Saraswat V, Shah S, Shiha G, Sharma BC, Sharma MK, Sharma K, Butt AS, Tan SS, Vashishtha C, Wani ZA, Yuen MF, Yokosuka O; APASL ACLF Working Party. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014. Hepatol Int. 2014 Oct;8(4):453-71. 
40. Bernardi M, Moreau R, Angeli P, Schnabl B, Arroyo V. Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis. J Hepatol. 2015 Nov;63(5):1272-84. 
41. Arroyo V, Moreau R, Jalan R, Ginès P; EASL-CLIF Consortium CANONIC Study. Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis. J Hepatol. 2015 Apr;62(1 Suppl):S131-43. 
42. Gustot T, Fernandez J, Garcia E, Morando F, Caraceni P, Alessandria C, Laleman W, Trebicka J, Elkrief L, Hopf C, Solís-Munoz P, Saliba F, Zeuzem S, Albillos A, Benten D, Montero-Alvarez JL, Chivas MT, Concepción M, Córdoba J, McCormick A, Stauber R, Vogel W, de Gottardi A, Welzel TM, Domenicali M, Risso A, Wendon J, Deulofeu C, Angeli P, Durand F, Pavesi M, Gerbes A, Jalan R, Moreau R, Ginés P, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL-CLIF Consortium. Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis. Hepatology. 2015 Jul;62(1):243-52. 
43. Jalan R, Pavesi M, Saliba F, Amorós A, Fernandez J, Holland-Fischer P, Sawhney R, Mookerjee R, Caraceni P, Moreau R, Ginès P, Durand F, Angeli P, Alessandria C, Laleman W, Trebicka J, Samuel D, Zeuzem S, Gustot T, Gerbes AL, Wendon J, Bernardi M, Arroyo V; CANONIC Study Investigators; EASL-CLIF Consortium. The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure. J Hepatol. 2015 Apr;62(4):831-40. Erratum in: J Hepatol. 2015 Jul;63(1):291. 
44. Jalan R, Saliba F, Pavesi M, Amoros A, Moreau R, Ginès P, Levesque E, Durand F, Angeli P, Caraceni P, Hopf C, Alessandria C, Rodriguez E, Solis-Muñoz P, Laleman W, Trebicka J, Zeuzem S, Gustot T, Mookerjee R, Elkrief L, Soriano G, Cordoba J, Morando F, Gerbes A, Agarwal B, Samuel D, Bernardi M, Arroyo V; CANONIC study investigators of the EASL-CLIF Consortium. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014 Nov;61(5):1038-47. 
45. Arroyo V, Moreau R. Tying up PGE2 with albumin to relieve immunosuppression in cirrhosis. Nat Med. 2014 May;20(5):467-9. 
46. Mehta G, Gustot T, Mookerjee RP, Garcia-Pagan JC, Fallon MB, Shah VH, Moreau R, Jalan R. Inflammation and portal hypertension - the undiscovered country. J Hepatol. 2014 Jul;61(1):155-63. 
47. Durand F, Buyse S, Francoz C, Laouénan C, Bruno O, Belghiti J, Moreau R, Vilgrain V, Valla D. Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography. J Hepatol. 2014 Jun;60(6):1151-7. 
48. Moreau R, Arroyo V. Acute-on-chronic liver failure: a new clinical entity. Clin Gastroenterol  Hepatol. 2015 May;13(5):836-41. 
49. Jalan R, Fernandez J, Wiest R, Schnabl B, Moreau R, Angeli P, Stadlbauer V, Gustot T, Bernardi M, Canton R, Albillos A, Lammert F, Wilmer A, Mookerjee R, Vila J, Garcia-Martinez R, Wendon J, Such J, Cordoba J, Sanyal A, Garcia-Tsao G, Arroyo V, Burroughs A, Ginès P. Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol. 2014 Jun;60(6):1310-24. 
50. Lemoinne S, Thabut D, Housset C, Moreau R, Valla D, Boulanger CM, Rautou PE. The emerging roles of microvesicles in liver diseases. Nat Rev Gastroenterol Hepatol. 2014 Jun;11(6):350-61. 
51. Francoz C, Nadim MK, Baron A, Prié D, Antoine C, Belghiti J, Valla D, Moreau R, Durand F. Glomerular filtration rate equations for liver-kidney transplantation in patients with cirrhosis: validation of current recommendations. Hepatology. 2014 Apr;59(4):1514-21. 
52. Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, Durand F, Gustot T, Saliba F, Domenicali M, Gerbes A, Wendon J, Alessandria C, Laleman W, Zeuzem S, Trebicka J, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL–CLIF Consortium. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013 Jun;144(7):1426-37, 1437.e1-9. 
53. Gandoura S, Weiss E, Rautou PE, Fasseu M, Gustot T, Lemoine F, Hurtado-Nedelec M, Hego C, Vadrot N, Elkrief L, Lettéron P, Tellier Z, Pocidalo MA, Valla D, Lebrec D, Groyer A, Monteiro RC, de la Grange P, Moreau R. Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis. J Hepatol. 2013 May;58(5):936-48. 
54. Rolas L, Makhezer N, Hadjoudj S, El-Benna J, Djerdjouri B, Elkrief L, Moreau R, Périanin A. Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis. Hepatology. 2013 Mar;57(3):1163-71.

Scientific summary

Dr. Richard Moreau is Director of the European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain. He is also Emeritus Senior Scientist at the INSERM (French NIH), Paris, France.

He obtained his MD degree in 1983 at the University of Paris, France. From 1983 to 1996, he was full-time physician at Intensive Care Units from Ile-de-France hospitals. In 1996, he joined the Liver Unit at Beaujon hospital as Consultant in Hepatology and got the position of Senior Scientist at the INSERM, and Principal Investigator at the INSERM Department located at Beaujon Hospital and involved in research on Liver Diseases.

His main research interest is pathophysiology and treatment of complications of cirrhosis, in particular systemic inflammation and acute-on-chronic liver failure (ACLF). In 2009, he was among the European hepatologists who created the EASL-Chronic Liver Failure (CLIF) Consortium, which is fully dedicated to research on cirrhosis. He was Principal Investigator of the first study (CANONIC study) performed under the umbrella of the EASL-CLIF Consortium. This prospective study enrolled 1343 patients with acutely decompensated cirrhosis admitted to 29 liver units from 8 European countries. The CANONIC study provided an evidence-based definition for ACLF. He was also Principal Investigator of the ACLARA study that recruited 1274 patients with acutely decompensated cirrhosis in 44 hospitals from 7 Latin American countries. The objectives of the ACLARA study was to assess the role of ethnicity, genetic ancestry, sociodemographic factors, in poor outcomes (ACLF, short-term death) of acutely decompensated cirrhosis.

 In 2016, the EASL-CLIF Consortium was enriched with a new branch called Grifols Chair; this enrichment gave rise to the EF Clif. The Grifols Chair is in charge to develop translational research on acutely decompensated cirrhosis. Dr. Moreau was Deputy Director of the Grifols Chair (2016-2021) and therefore involved in the development of multi-omics approaches (including metabolomics, lipidomics, transcriptomics, GWAS) using biological samples from patients enrolled in the clinical studies sponsored by EF CLIF

He was successively Special Section Editor (2020-2021), Senior Editor of Journal of Hepatology (2015-19) and Associate Editor (2010-14), at Journal of Hepatology. He was also Associate Editor at Liver International (2007-2009).

He is member of EASL, AASLD (FAASLD since 2022), APASL, French Association for the Study of the Liver (AFEF), Club Francophone pour l’Etude de l’Hypertension Portale.