CV Science

Etienne Joly MD MSc

Course and current status

EDUCATION:

MEDICAL:

            -1979/1985:             Medical school, Université Paris V, CHU Paris-Ouest.

            -1985/1987:             Intern in general medicine, Université Paris V.

            -1988:                     Thesis of Medicine, Université Paris V.

SCIENTIFIC:

            -1983/1984:             Licence de biologie cellulaire, Université Paris VI.

            -1984/1985:             Maîtrise de biologie cellulaire, Université Paris VI

                        (equivalent to a Bachelors degree),

                        Options: Molecular biology, Molecular biophysics, Membrane biophysics

            -1985/1986: DEA de Génétique (Prof. Piotr Slonimsky), Université Paris VI

                        (equivalent to a Masters degree).

            -1987:             Course of General Virology at the Pasteur Institute.

            -2000:             HDR, Université Paul Sabatier, Toulouse

LABORATORY EXPERIENCE:

- 1982: Laboratory of Dr. Jacques Leibowitch, Hôpital Raymond Poincaré, 92380 Garches.
      Subject: Study of circulating immunoglobulins in patients with Berger's nephropathy.

- 1984: Laboratory of Prof. A.D. Strosberg, Institut Jacques Monod, Paris.
     Subject: Biochemical characterisation of the human ß2 adrenergic receptor.

- 1986: Laboratory of Prof. F. Jacob, group of Dr. J. F. Nicolas, Institut Pasteur, Paris.
     Subject: Optimisation of retroviral vector usage for transfecting tissue culture cells.

- 02/88 - 02/91: Laboratory of Prof. M.B.A. Oldstone, Scripps Clinic, La Jolla, California.
     Subject: Role of MHC class I antigens in presenting LCMV epitopes to CTLs.

- 03/91 - 09/92: Laboratory of Dr. J. Williams, ICRF Clare Hall Laboratories, England.
     Subject: Development of an enhancer trap in Dictyostelium discoideum.

- 10/92 - 03/99: Laboratory of Immunogenetics, The Babraham Institute, Cambridge, UK. Subjects:

         1) Characterisation of functional interactions between alleles of MHC class I molecules and TAP transporters.
         2) Analysis of the molecular mechanisms controlling the down-regulation of MHC class I expression in nervous tissues. 

- 04/99 - 08/05 : Group leader of Neuro-Immuno-Genetics research team.
     Institut Claude de Préval, CHU Purpan, Toulouse.

      Subjects:
        Evolution of MHC class I molecules
        Expression and functionnal role of MHC molecules in the CNS.
        Trogocytosis: How does it work, and why ?
        How does the physical state of biological membranes relate to their functions ?

- 09/05- today: Group leader of Neuro-Immuno-Genetics research team. IPBS, Toulouse.

     Subjects:
      1) Does MeCP2  have immunomodulatory roles ?
      2) Trogocytosis: How does it work, and why ? And how can we exploit it ?
      3) How does the physical state of biological membranes relate to their functions ?             4) The role of recessive mutations and inbreeding in processes of speciation.

Scientific summary

Interested in MHC class I molecules and immunogenetics for many years, in particular regarding rat MHC class I molecules. Other interests include neuroimmunology, Rett syndrome and MeCP2, trogocytosis, membrane biophysics, and more recently, evolution and speciation. I am also a very dedicated advocate of open access publishing, and hope that it will it will soon become the norm. I am also trying to contribute to the setting up of unique scientific author identification (or SLIP, for Scientist LIcense Plate), in particular via the recent ORCID initiative.