CV Science

Jean-Noel Freund PhD, Molecular and Cellular Biology

Course and current status

PhD, University Louis Pasteur, Strasbourg (1986): « Structural and Functional Organization of the rudimentary locus of Drosophila melanogaster »     (supervisor: Prof. P Chambon, Inserm U184 / LGME)

Inserm U61 (1987 – 1992): Junior Scientist - Team « Intestinal Lactase »

Inserm U381 (1993 – 2004): Team Leader « Genetic regulation of intestinal differentiation; Lactase »

Inserm U682 (2005 – 2012): Team Leader « Transcription Factors and Signaling Pathways in Development, Homeostasis and Pathology of the Digestive Tract »

Inserm U682 (2012): Acting Director « From Tissue Homeostasis to Inflammation and Cancer »

Inserm UMR-S1113 / IRFAC (2013 – 2023): Director « Interface between Fundamental and Applied Cancer Research » ; Team Leader " Stem Cell Emergence and Tumor Initiation"

Inserm U1256 (2024 - 2025 [retirement]): Senior Scientist " Nutrition, Genetics and Envitonment Risk Exposure" 

Scientific summary

Research area

>> Pyrimidine pathway in Drosophila melanogaster

>> Intestinal Lactase - Hypolactasia

>> Development, homeostasis and cancer of the digestive tract - CDX homeobox genes 

>> Hematopoietic emergence and leukemia - CDX homeobox genes

>> One-carbon metabolism in Cancer Stem Cells