Jean-Noel Freund
  • E-mail :[email]
  • Phone : +33 3 72 74 61 35 (std)
  • Location : INSERM U1256 - NGERE, Vandoeuvre-lès-Nancy, France
Last update 2023-12-30 14:24:02.13

Jean-Noel Freund PhD, Molecular and Cellular Biology

Course and current status

Current Position

Inserm U1256 / NGERE – Lorraine University (2024 - current) Senior Scientist « Nutrition, Genetics and Environment Risks Exposure »

Career    

PhD, University Louis Pasteur, Strasbourg (1986): « Structural and Functional Organization of the rudimentary locus of Drosophila melanogaster »     (supervisor: Prof. P Chambon, Inserm U184 / LGME)

Inserm U61 (1987 – 1992): Junior Scientist - Team « Intestinal Lactase »

Inserm U381 (1993 – 2004): Team Leader « Genetic regulation of intestinal differentiation; Lactase »

Inserm U682 (2005 – 2012): Team Leader « Transcription Factors and Signaling Pathways in Development, Homeostasis and Pathology of the Digestive Tract »

Inserm U682 (2012): Acting Director « From Tissue Homeostasis to Inflammation and Cancer »

Inserm UMR-S1113 / IRFAC (2013 – 2023): Director « Interface between Fundamental and Applied Cancer Research » ; Team Leader " Stem Cell Emergence and Tumor Initiation"


Scientific summary

Research area

>> Pyrimidine pathway in Drosophila melanogaster

>> Intestinal Lactase - Hypolactasia

>> Dvelopment, homeostasis and cancer of the digestive system - CDX homeobox genes 

>> Hematopoietic emergence and leukemia - CDX homeobox genes

>> One-carbon metabolism in Cancer Stem Cells

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