• E-mail :[email]
  • Phone : +33 4 26 55 67 48
  • Location : Lyon, France
Last update 2020-11-19 10:26:10.533

Julien MARIE PhD in immunology, immuno-virology

Course and current status

Current position

Since 2019   Head of the  departement Tumor Escape Resistance and Immunity
                    CRCL, Inserm 1052, CNRS 5286 Cancer Hospital Léon Bérard

Since 2013   Director research INSERM 

Since 2013   In charge of the Immunology Virology and cancer program of the master  of oncology of  University Lyon 1

Since 2009   Head of the TGF-beta and Immune Evasion Lab,  C R C L,  Lyon france

Education and academic positions

1999-2002: PhD in immunology, Topic: regulation of inflammatory responses by Measles virus proteins). Ecole Normale Supérieure de Lyon

2003-2005: PostDoc Follow, Topic: regulation of T cell responses. Prof A. RUDENSKY, Univ of Washington, Seattle USA, Human Frontier Science Program Fellow

2005: Chargé de  recherche Inserm ( unior permanant researcher)

2006-2009: Head of TGF-beta and Immune evasion lab, ENS, Lyon

2013-2018    Director of the Inserm Helmholtz lab, Lyon  (France ) DKFZ Heidelbreg    Germany

Scientific summary

Julien Marie hold is PhD in Immuno-virology  from Ecole Normale Superieure of Lyon in 2002. After working on the immunosupression induced by virus ( Immunity 2000, Nature Immunology 2002). Julien Marie obtained a Human Frontier Science Program fellowship and  joined the Rudensky lab inthe USA. There he focused  his ivestigations on the  effects of Transforming Growth Factor beta ( TGF-ß) on T lymphocyte biology and their consequences on autoimmune diseases (Immunity 2006, J.exp med 2005). back to france,  ussing  different approaches, ranging from in vivo to gene regulation  levels,  his lab demonstrated that TGF-beta control the developpment and functions of key T cells subsets including NKT cells ( J. Exp. Med. 2009, Blood 2012), TFH cells ( J. Clin. Invest. 2014), CD8 effector and memory  T cells,  ( Immunity 2012, Nature Com. 2014), Treg (immunity 2015 Nature Immunol 2020) and thymic selection  (Nature Com 2019) with  consequences on autoimmune disease and infections. His lab research  is also focused on the regulation of the  T cell response in cancers (Cancer resarch 2020) and in  cancer associated inflammation in the intestine.

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