CV Science

Julien MARIE Director of Research (DR1)

Course and current status

Current position

Since 2019   Head of the  department "Tumor Escape Resistance and Immunity" 13 teams
                    CRCL, Inserm 1052, CNRS 5286 Cancer Hospital Léon Bérard

Since 2013   Director of  research INSERM 

Since 2013   In charge of the Immunology and cancer program of the master  of oncology of  University Lyon 1

Since 2009   Head of the TGF-beta and Immune Evasion Lab,  C R C L,  Lyon france

Education and academic positions

1999-2002: PhD in immunology immuno virology, Topic: regulation of inflammatory responses by Measles virus proteins). Ecole Normale Supérieure de Lyon

2003-2005: PostDoc Follow, Topic: regulation of T cell responses. Prof A. Rudensky Univ of Washington, Seattle USA, Human Frontier Science Program Fellow

2005: Chargé de  recherche Inserm ( tenure position)

2006-2009: Head of TGF-beta and Immune evasion lab, ENS, Lyon

2013-2018    Director of the Inserm Helmholtz lab, Lyon  (France ) DKFZ Heidelbreg    Germany

Scientific summary

Julien Marie hold is PhD in Immuno-virology  from Ecole Normale Superieure of Lyon in 2002. After working on the immunosupression induced by Measles virus ( Immunity 2000, Nature Immunology 2002), Julien Marie obtained a Human Frontier Science Program fellowship and  joined the Rudensky lab in Seattle USA. There, he focused  his ivestigations on the  effects of Transforming Growth Factor beta (TGF-ß) on T lymphocyte biology and their consequences on autoimmune diseases (Immunity 2006, J.exp med 2005). Back to France,  using  different approaches, ranging from in vivo to gene regulation  levels,  his lab demonstrated that TGF-beta control the developpment and functions of key T cells subsets including NKT ( J. Exp. Med. 2009, Blood 2012,) TFH cells ( J. Clin. Invest. 2014), CD8 effector and memory  T cells,  ( Immunity 2012, Nature Com. 2014, Nature Immunology 2020 J clin invest 2022), Treg (immunity 2015 Nature Immunol 2020, Nature com 2021, Nature 2022) and thymic selection  (Nature Com 2019) with  consequences on autoimmune disease and infections. His lab research  is also focused on the regulation of the  T cell response in cancers (Cancer resarch 2020, Nature com 2020) and in  cancer associated inflammation in the intestine in cluding microbiota (Nature 2022, Nature Immunology 2024). Dr Marie was awarded of numerous prizes including the  Jules Courmont academy of science (2007, Lyon), fondation Bettencourt-Schuller Prize (2011 Paris)  the French Society of immunology (2010 Paris ) The  European I award sanofi (2019), the  Descroix Vernier Bioethics prize (2022, Paris)