• E-mail :[email]
  • Phone : +33 5 57 5746 42
  • Location : Bordeaux, France
Last update 2011-08-25 10:26:26.583

Jean-Pierre Savineau Professor, PhD

Course and current status


. Ph.D. in Physiology, University of Poitiers (France), 1978

. Doctorat d’Etat ès sciences, University of Bordeaux 2 (France), 1987


. Post-Doctorat on a scholarship from the French Dpt. of education:  1979-1981

. Lecturer and Senior lecturer in Physiology, Faculty of Pharmacy, University    Bordeaux2:   1981-1997

 . Professor of Physiology (full Professor), Faculty of Life Sciences, University Bordeaux2:   1998-2011

Administrative position:

. Director of the faculty of life sciences of the University Bordeaux 2 (2001-2006)

. Member of the Scientific council of the university Bordeaux2  (2008-2011)

. Member of the scientific board of the doctoral school of Bordeaux (2001-2010)


Teaching responsibilities:

- head of the physiological department of the faculty of life sciences; responsible of the master speciality "Cell biology and Pathophysiology”.











Scientific summary

Research specialization:

-          main field: physiology, pharmacology and pathophysiology of mammalian smooth muscles; physiopathology of the pulmonary circulation (effect of hypoxia); pulmonary artery hypertension.

-          Specific interest: calcium homeostasis, electrophysiology, ionic channels, smooth muscle contractile apparatus, phosphodiesterases, reactive oxygen species, DHEA.

Research responsibilities: Head of the team n°1 “Pathophysioloy of the pulmonary circulation” at the Cardio thoracic Research Center of Bordeaux, INSERM unit 1045.

Membership of professional Societies :

 The British Pharmacological Society (since 1993), The French Physiological Society (since 1985), The French Pharmacological Society (since 1989), The European Biomedical Research Association (since 1994)


Number of papers in refereed journals: 94; number of invited reviews and book chapters: 18; number of communications to scientific meetings (with publication): 170. H factor 2011 (webb of sciences) = 27.

The most relevant publications during the last 5  years:


E. Dumas de la Roques, J.P. Savineau, S. Bonnet. Dehydroepiandrosterone a new treatment for vascular remodeling diseases including pulmonary arterial hypertension. Pharmacology &Therapeutics, 2010, 126 (2), 186-199.

 T. Ducret, J. El Arrouchi, A. Courtois, J.F. Quignard, R. Marthan, J.P. Savineau. Characterization of stretch-activated channels in rat intrapulmonary arterial smooth muscle cells. Cell Calcium, 2010, 2251-259.

M. Billaud, R. Marthan, J.P. Savineau, C. GuibertVascular smooth muscle cells limit endothelial control of vasoreactivity via ROS production through myoendothelial communications. Plos One, 2009, 4(7) :e6432

 L. Rodat-Despoix, V. Aires, T. Ducret, R. Marthan, J.P. Savineau E. Rousseau, C. Guibert. Signalling pathways involved in the contractile response to 5-HT in human pulmonary artery. European Respiratory Journal, 2009, 34(6):1338-47.

 T. Ducret, C. Guibert, R. Marthan, J.P. Savineau. Serotonin-induced activation of TRPV like current in rat intrapulmonary arterial smooth muscle cells. Cell Calcium, 2008, 43(4):315-23.

 C. Guibert, Th. Ducret, J.P. Savineau. Voltage-independent calcium influx in smooth muscle. Progress in Biophysics and Molecular Biology, 2008, 98, 10-23.

C. Guibert, R. Marthan, J.P. Savineau. Modulation of ion channels in pulmonary arterial hypertension. Current Pharmaceutical Design, 2007, 13(24), 2443-2455.

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