Scientific topics
Keywords
Jean-Pierre Savineau Professor, PhD
Course and current status
Education:
. Ph.D. in Physiology, University of Poitiers (France), 1978
. Doctorat d’Etat ès sciences, University of Bordeaux 2 (France), 1987
Career:
. Post-Doctorat on a scholarship from the French Dpt. of education: 1979-1981
. Lecturer and Senior lecturer in Physiology, Faculty of Pharmacy, University Bordeaux2: 1981-1997
. Professor of Physiology (full Professor), Faculty of Life Sciences, University Bordeaux2: 1998-2011
Administrative position:
. Director of the faculty of life sciences of the University Bordeaux 2 (2001-2006)
. Member of the Scientific council of the university Bordeaux2 (2008-2011)
. Member of the scientific board of the doctoral school of Bordeaux (2001-2010)
Teaching responsibilities:
- head of the physiological department of the faculty of life sciences; responsible of the master speciality "Cell biology and Pathophysiology”.
Scientific summary
Research specialization:
- main field: physiology, pharmacology and pathophysiology of mammalian smooth muscles; physiopathology of the pulmonary circulation (effect of hypoxia); pulmonary artery hypertension.
- Specific interest: calcium homeostasis, electrophysiology, ionic channels, smooth muscle contractile apparatus, phosphodiesterases, reactive oxygen species, DHEA.
Research responsibilities: Head of the team n°1 “Pathophysioloy of the pulmonary circulation” at the Cardio thoracic Research Center of Bordeaux, INSERM unit 1045.
Membership of professional Societies :
The British Pharmacological Society (since 1993), The French Physiological Society (since 1985), The French Pharmacological Society (since 1989), The European Biomedical Research Association (since 1994)
Publications:
Number of papers in refereed journals: 94; number of invited reviews and book chapters: 18; number of communications to scientific meetings (with publication): 170. H factor 2011 (webb of sciences) = 27.
The most relevant publications during the last 5 years:
E. Dumas de la Roques, J.P. Savineau, S. Bonnet. Dehydroepiandrosterone a new treatment for vascular remodeling diseases including pulmonary arterial hypertension. Pharmacology &Therapeutics, 2010, 126 (2), 186-199.
T. Ducret, J. El Arrouchi, A. Courtois, J.F. Quignard, R. Marthan, J.P. Savineau. Characterization of stretch-activated channels in rat intrapulmonary arterial smooth muscle cells. Cell Calcium, 2010, 2251-259.
M. Billaud, R. Marthan, J.P. Savineau, C. Guibert. Vascular smooth muscle cells limit endothelial control of vasoreactivity via ROS production through myoendothelial communications. Plos One, 2009, 4(7) :e6432
L. Rodat-Despoix, V. Aires, T. Ducret, R. Marthan, J.P. Savineau E. Rousseau, C. Guibert. Signalling pathways involved in the contractile response to 5-HT in human pulmonary artery. European Respiratory Journal, 2009, 34(6):1338-47.
T. Ducret, C. Guibert, R. Marthan, J.P. Savineau. Serotonin-induced activation of TRPV like current in rat intrapulmonary arterial smooth muscle cells. Cell Calcium, 2008, 43(4):315-23.
C. Guibert, Th. Ducret, J.P. Savineau. Voltage-independent calcium influx in smooth muscle. Progress in Biophysics and Molecular Biology, 2008, 98, 10-23.
C. Guibert, R. Marthan, J.P. Savineau. Modulation of ion channels in pulmonary arterial hypertension. Current Pharmaceutical Design, 2007, 13(24), 2443-2455.
