CV Science

Dorine Neveu PhD

Course and current status

1977- 1981 Ecole Normale Supérieure Fontenay aux Roses, France

1980 Agregation, life sciences

1993 PhD, University Montpellier,1, France, Title. "Diversité, régulations et modulation phénotypique des canaux calciques activés par le voltage dans les myocytes  aortiques de rat adulte, en culture"

1993-94 Post-doc, University Montpellier 1, France, Boucard's lab, physiology

1994-1995 Post-doc University of California - Berkeley, Zucker's lab, neurophysiology

2002-06 Post-doc, University Montpellier 1, départment of medical information, University Hospital, Montpellier, France, clinical research, biostatistics

2006 Assistant professor, University Montpellier 1

Scientific summary

I first addressed the issue of the role of intracellular calcium signal in various models.With the patch-clamp technique, we characterized the electrophysiological and pharmacological properties of three voltage activated calcium channels in rat aortic myocytes in culture and studied their beta adrenergic regulation. We showed a differential expression as a function of cellular phenotype. Then we addressed the issue of the role of the intracellular Ca2+ signal in long-term potentiation (LTP) and long-term depression (LTD) and showed that similar intracellular Ca2+ elevation in CA1 pyramidal neuron induced long-lasting potentiation and long-lasting depression that share common mechanisms with LTP and LTD.

I turned then to the methodology and biostatistics used in clinical research and epidemiology. I contributed to study designs, protocol writing, and data analyses in various clinical areas. This involvement motivated statistical developments. A study which aimed at measuring intra and inter-observer agreement motivated the development of a new statistics, dzeta, that measures agreement for ordered ratings with 3 categories. I also computed the corrections to the asymptotic distribution of such statistics based on multinomial distribution. I also used a Markov model in a medico-economic study that aimed at evaluating the cost-efficacy of the surgery of epilepsy.

Now I contribute to studies related to HIV: an international clinical trial aiming at comparing two antiretroviral drugs in the prevention of mother to child transmission of HIV through breastfeeding; an observational study aiming at determining whether co-infection HIV - tuberculosis favours emergence of Mycobacterium Tuberculosis strains. I also address the issue of stress in students. I have coordinated a cross-sectional study in order to determine whether the academic program predicts a high level of perceived stress, irrespective of personal and environmental factors, and coping strategies.