CV Science

Sophie Langouet PhD Research Scientist

Course and current status

A. Education

 1986 : Baccalaureat (option Biology)

1990 : License of Biochemistry, University of Rennes 1

1991 : Master in Biochemistry, University of Rennes 1

1992 : Diploma in Toxicology, University of Paris V

1995 : European PhD of Toxicology, in Paris V University. Research prepared in Unit of Hepatologic researches in the National Institute of Health and Medical Research, Rennes, France on : Expression and regulation of glutathione s-transferases in rodent and human hepatocytes and their potential role in the detoxication of aflatoxin B₁.

2007 : Habilitation to direct research, University of Rennes 1

B. Positions and Honors

Positions and Employment 

1996 - 1997     Research fellow, Vanderbilt University, Nashville TN (Site specific mutagenesis of vinyl chloride DNA adducts)

1997 - 2000     Research fellow, National Institut of Health and Medical Research (Inserm), Rennes, France (Metabolism of carcinogens and DNA adducts formation, strategies for chemoprevention)

2000 -              Research scientist (permanent position), Inserm, Rennes, France (Expression and regulation of nucleotide excision repair in human liver)

Honors

1996         :    Young Scientist of Brittany Award

1997         :    Langlois Foundation Award

2000         :    French Society of Toxicology Award

Scientific summary

Expertise: Cellular and Molecular Toxicology in the health and environment sector.

My research programs focus on the implication of signaling pathways in cell differentiation, especially in normal and cancerous hepatocytes from human origin. We deal with metabolism activation of carcinogens in human hepatocytes in primary culture. The DNA adduct formation in this state-of-the-art model is one of our priority as well as the regulation of DNA repair pathways responsible for their elimination.