CV Science

Jochen Lang MD, diabetes, biosensors, islets, exocytosis (Bordeaux)

Course and current status

• EDUCATION: Jochen LANG studied medecine as a fellow of the German University Foundation in Germany (Würzburg U., Freiburg U.), France (Paris VI) and Switzerland (Geneva University). Clinical clerkships in the US (Penn. State U.) and Canada (Bella Coola Indian Reserve, BC). Federal licence as practitioner and the FMGEMS (US) in 1984. Thesis in neuropharmacology 1984. Postdoc Max-Planck-Institut, Martinsried, 1985-1988. Privatdocent (HDR), Université de Genève, 1997.

• CAREER: Internship in Internal Medecine 1988-1990 (Geneva University Hospital). 1990-2000 Assistant and Associate Professor in Pr. C.B. Wollheim’s group (Experimental Diabetology, Centre Medical Universitaire, Geneva) developing approaches on ß-cells as a model for vesicular transport and its regulation. Prix Denber-Pinard. In 2000 he joined the University of Bordeaux and created a cell biology

• ADMINISTRATIVE POSITIONS: Deputy Director of the Bordeaux Health and Life Sciences doctoral School (2007-) Member of the Scientific Council of the University Bordeaux 1 (2004-2008) Member of the Administration Council of the University Bordeaux 1 (2008-2012) Member elected of the National Comittee, CNRS, section 22 (Cell and Developmental Biology) Codirector of the master speciality "Cell Biology and Pathophysiology”

• PUBLICATIONS RESEARCH ID
  
• FULL CV

Scientific summary

KEYWORDS:Vesicular Traffic, Diabetes, Islets, Beta-cells, Exocytosis, Siganlling, BiosensorsMolecular Cell Biology, Electrophysiology, Transgenics

Type 2 diabetes, a lifelong, incapacitating disease, affects 5% of the population in Europe and its complex aetiology includes alterations of pancreatic ß-cells and insufficient insulin secretion as an important facet. Insulin-secreting pancreatic ß-cells and islets play a major role in nutrient homeostasis and provide a powerful model to dissecate mechanisms and regulation of vesicular transport and fusion with the plasma membrane. Our studies on pancreatic ß-cells have the fllwoing major goals:

•  Gaining insight in the interplay between proteins at different stages of exocytosis and regulatory events, understanding the interactions in physicochemical terms in membranes and at the membrane/cytosol interface. READ MORE.

• Investigate the regulation of ß-cells, glucose signaling and the contribution of exocytotic proteins to diabetic syndromes. READ MORE.

•  The development of novel bioelectronic sensors using islet cells. READ MORE.

We use different means such as biochemistry, molecular cell biology, imaging, electrophysiology and functional genomics on clonal or primary ß-cells derived from islets (rat, murine, human). We have recently embarked on the use of transgenic models.