CV Science

Etienne Ruppé PhD Infectious diseases

Course and current status

Etienne Ruppé (PharmD, PhD) is a clinical bacteriologist. After studying Pharmacy and Medical Biology at the Universities of Tours and Paris Descartes, he worked on the development of an automated detection system for the main antibiotic resistance genes in the intestinal microbiota in the bacteriology laboratory of the Bichat-Claude Bernard Hospital (Prof. Antoine Andremont) in Paris, within the framework of the NOSOBIO project (financed in part by the OSEO investment bank). Then he was appointed Assistant Professor in the University Paris Diderot and in the bacteriology laboratory of the Bichat-Claude Bernard hospital (Prof. Antoine Andremont) in Paris. He did his PhD on the epidemiology of commensal, multidrug-resistant Enterobacterales and participated as scientific leader in the VOYAG-R project which aimed to measure the rate of acquisition of multidrug-resistant enteric bacteria during travel in tropical areas. He then left for a first post-doctoral internship in the pre-industrial demonstrator MetaGenoPolis created by Prof. Dusko Ehrlich and Prof. Joël Doré of INRA in Jouy-en-Josas. Within the framework of the European project EvoTAR, he worked on the identification of antibiotic resistance genes in the intestinal microbiota and their dynamics during various antibiotic exposures. He then did a second post-doctoral fellowship in the genomic research laboratory of the University Hospital of Geneva (Prof. Jacques Schrenzel) where he worked on the development of clinical metagenomics. With Prof. Schrenzel, he notably founded the first International Conference on Clinical Metagenomics (ICCMg) in Geneva, of which six editions have been held to date. In 2017, he was appointed Assosciate Professor at the University of Paris Diderot and the Bichat-Claude Bernard Hospital, then Full Professor at the University of Paris in 2021. His area of expertise is antibiotic resistance in a global approach.

Scientific summary

My research focuses on antibiotic resistance, in particular on the interactions between microbiota and the emergence of resistant bacteria, the dynamics of antibiotic resistance genes (the resistome) and the diagnosis of infections, using new sequencing tools